Background:  

    Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes

    belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). 

    Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which 

    localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is 

    mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The 

    protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It 

    plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with t

    he pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants.