Background:  

    The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase 

    superfamily.This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface 

    protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and

    tyrosine autophosphorylati on and leads to cell proliferation. Mutations in this gene are associated with lung cancer.

    EGFR is a component of the cytokine storm which contributes to a severe form of coronavirus disease 2019 (COVID-19)

    resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).